Unmet Need

VCC-001

VCC-001, the most advanced product candidate demonstrated clinical efficacy and a favorable safety profile in several clinical trials. 1, 2, 3, 4 The availability of clinical data that have been obtained in >1000 patients reduces risk of failure of future clinical trials I.

Mechanism of Action: Inducing a specific immune response against
the patientʼs tumour based on the individual antigen profile
to enable the immune system to recognize and attack the tumour.

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Only One In 10,000 Substances Tested In Research
Laboratories Will Eventually Become A Drug After About
12 Years. The Cost Is 1–1.5 Billion Us Dollars.

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Phase III Clinical Study:
VCC-001 has already demonstrated significant
clinical efficacy in phase III in 553 patients with
RCC post-nephrectomy.

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VCC-001 DEMONSTRATED favorable
safety profile in phase III

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• In the Intention to treat population 177 patients received A total of 1053 vaccine doses
• 12 vaccine-related adverse events of mild to moderate severity were noted in two patients
• The higher number of adverse events in the control groups can be accounted for by the higher number of patients
  with tumour progression in this group
• Clinically relevant abnormalities in blood chemistry variables were not recorded

The Vaccentis Pipeline is expanded by research and preclinical testing in the following indications

VCC-002 :Metastatic Renal Cell Carcinoma. 

VCC-003: Colorectal Cancer

VCC-004: Lung Cancer 

VCC-005: Bladder Cancer 

1. Repmann et al., 2003 Anti Cancer Research 23: 969-974

2. Jocham et al., 2004 Lancet 363:594-99

3. Doehn et al., 2006 Supplement Journal of Urology 5(20): 286

4. May et al., 2009 Cancer Immunol Immunotherap 59(5):687-95